In order to solve the problems of a hypersonic wind tunnel measurement system such as equipment aging, serious degradation performance of the data acquisition channel, and many signal line switching links, the development of a new measurement system was carried out. The new measurement system is based on PXI bus,using high-precision signal conditioning system and multiple types of data acquisition cards. The software adopts a modular and multi-thread design mode, integrating force measurement, pressure measurement and thermal measurement tests, and can achieve flexible configuration of various test types. After experimental testing, the error limit of the measurement system is better than 0.03%. The wind tunnel velocity field, temperature field and standard model test results meet with the requirements of the national standard. The new measurement system has good stability, high reliability and high acquisition accuracy,which can meet the needs of advanced aircraft testing.