Aiming at the problems of air conditioning monitoring system by the bus system, such as high cost of wiring construction, complex network structure, and difficult maintenance. In this paper, a design of smart campus air conditioning monitoring system based on 6LoWPAN is proposed. First of the paper, all function and the network architecture of the system are described. The second is talking about the hardware design of sensor nodes, gateway node and the system core module. The Next is describing simplify of 6LoWPAN protocol and proposing the design of the system embedded software. Finally, the relevant air-conditioning control strategy is introduced. Test and experimental results show that the advantages of air conditioning monitoring system are simple structure, high scalability and real-time response. It effectively solves the problem of connecting air conditioning with the Internet, and makes use of cloud platform for smart management to achieve the targets of energy saving and emission reducing.