Due to the presence of multiple devices in a small space, cosite interference is very common in the modern communications platform .To reduce the influence of cosite interference on the receiver performance, a kind of adaptive interference canceller based on orthogonal vector synthesis is designed. According to the characteristics of extracted data from the DSP control unit, pattern search is proposed as a controller algorithm and improved. Simulation analysis are carried out using actual measurement data. The results show that, compared with the PSA algorithm, simulated annealing algorithm, genetic algorithm, the improved PSA algorithm has faster convergence speed, while convergence accuracy is almost the same. Finally the algorithm is implemented in DSP and interference cancellation ratio is measured in the 100-500 MHz frequency range. The final implementation results show that this method can meet the performance requirements. Most frequency points can reach 40 dB, meeting the performance requirements. As can be seen, the pattern search algorithm has strong local search ability and the advantage of easy to implement in engineering,suitable for optimization process that requires fast convergence.