In the process of deployment of methanol-gasoline existed the problem of large inertia, time delay, strong coupling and uncertainty, the conventional control algorithm is difficult to achieve good control effect. DMC algorithm be used through model predicts, online rolling optimization and error correction etc, when there is no accurate model case, it can achieve good control of the control performance. Therefore, this paper proposed a dynamic matrix predictive control method based on OPC technology and MATLAB OPC Toolkit. This results show that the proposed control system has high control accuracy, strong anti-interference ability, strong robustness.